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Updating clinical guidelines

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In addition, recent data indicate that Zika virus RNA might be detected in the serum or urine of some asymptomatic pregnant women (7).

The frequency of this finding is unknown, but the detection of Zika virus RNA in serum or urine provides a definitive diagnosis of Zika virus infection.

Individuals who served on the Clinical Guidelines Committee from initiation of the project until its approval were Thomas D. Barry, MD†; Molly Cooke, MD†; Nick Fitterman, MD†; Russell P. Humphrey, MD, MPH†; Devan Kansagara, MD, MCR†; Robert M. The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; systematic reviews; large observational studies (for adverse events); and case reports (for rare events) that were published between 2 January 2005 and 3 June 2011. To increase the proportion of pregnant women with Zika virus infection who receive a definitive diagnosis, CDC recommends expanding real-time reverse transcription–polymerase chain reaction (r RT-PCR) testing. health care providers caring for pregnant women with possible Zika virus exposure, to include the emerging data indicating that Zika virus RNA can be detected for prolonged periods in some pregnant women.Zika virus has also been linked to other adverse pregnancy outcomes, including miscarriage and stillbirth (1,2). As of July 14, 2016, a total of 400 women in the 50 U. states and the District of Columbia, and 378 women in all U. territories (aggregated territories’ data from the USZPR and ZAPSS) were determined to have laboratory evidence of confirmed or possible Zika virus infection during pregnancy.Data from the USZPR and published case reports indicate that Zika virus RNA can persist in serum of some pregnant women longer than had been previously reported; the longest documented duration of Zika virus RNA detection in serum is 10 weeks after symptom onset (4–7).This is probably due, among other reasons, to the likely assumption that it is similar to the development process.